Suboptimal Vitamin D Status Is Associated with Salmonella Infection and Elevated C-Reactive Protein in Hospitalized Children with Acute Gastroenteritis: A Retrospective Cohort Study

Nutrients 2026 Open access

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Authors: Hua-Hsi Hung, Hung-Chang Lee, C. Y. Yeung, Wai‐Tao Chan, Szu-Wen Chang, Fang‐Ju Sun, Chuen‐Bin Jiang
DOI: 10.3390/nu18050827
Cited by: 1
References: 24

Abstract

Background: Vitamin D contributes to intestinal barrier integrity and innate immune regulation, but its role in susceptibility to Salmonella infection and systemic inflammation in hospitalized pediatric patients with acute gastroenteritis (AGE) remains unclear. Methods: We retrospectively analyzed 70 pediatric patients hospitalized with AGE, examining the associations of admission 25(OH)D levels with culture-confirmed Salmonella infection and C-reactive protein (CRP). Multivariable logistic and linear regression models were adjusted for age and sex. Vitamin D status was classified as sufficient (≥30 ng/mL), suboptimal (

Fields of Study & Subjects

Vitamin D Research Studies Vitamin C and Antioxidants Research Digestive system and related health

Publication details

Journal / source
Nutrients
Publisher
MDPI AG
Volume
18
Issue
5
Pages
827–827
Publication date
3 March 2026
Language
EN