Synthesis and Evaluation of Cytotoxic Activity of 2-Aryl-2-(3-Indolyl)Propionic Acid Derivatives

Organics 2026 Open access

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Authors: Alexander V. Aksenov, Nicolai A. Aksenov, Nikolai A. Arutiunov, Дмитрий А. Аксенов, Anna M. Zatsepilina, Daria I. Murashkina, Maksim O. Shcheglov, Сергей Н. Овчаров
DOI: 10.3390/org7010011
Cited by: 0
References: 12

Abstract

2-Aryl-2-(3-indolyl)acetohydroxamic acids have emerged as promising antitumor agents; however, their poor pharmacokinetic profile remains a significant drawback. To address this limitation, we have synthesized a homolog of such acids—specifically 2-aryl-2-(3-indolyl)propionic acid (IC50 > 100 mM (U87)), along with several other derivatives: ethyl ester (IC50 > 100 mM (U87)), hydroxamate (IC50 21.2 ± 1.0 mM (U87)) and hydrazide (IC50 > 100 mM (U87)). The cytotoxicity of these compounds against glioblastoma cell lines was evaluated and compared to that of the parent acetohydroxamic acid derivatives.

Fields of Study & Subjects

Heterocyclic Compound Synthesis and Bioactivity Synthesis and bioactivity of alkaloids Synthesis and Characterization of Heterocyclic Compounds

Publication details

Journal / source
Organics
Volume
7
Issue
1
Pages
11–11
Publication date
3 March 2026
Language
EN