Age-Dependent Dynamics of the Biliary Microbiome in Children with Choledochal Cysts: Functional Remodeling Underlying Taxonomic Conservation

Pathogens 2026 Open access

Read full text
Authors: Xueqi Wang, Xueqi Wang, Ran Duan, Anxiao Ming, Yifan Zhang, Tiezhu Liu, Xin Wang, Xin Wang, Mei Diao
DOI: 10.3390/pathogens15020147
Cited by: 0
References: 15

Abstract

Choledochal cyst (CC), a congenital biliary anomaly, is associated with recurrent infections, chronic inflammation, and an increased risk of malignancy. Although emerging evidence implicates the biliary microbiome in disease pathophysiology, its developmental dynamics in pediatric CC remain unclear. Using deep metagenomic sequencing and comprehensive functional annotation, this study characterized age-dependent changes in the biliary microbiome of 201 pediatric CC patients stratified into infancy (

Fields of Study & Subjects

Gut microbiota and health Pediatric Hepatobiliary Diseases and Treatments Cholangiocarcinoma and Gallbladder Cancer Studies

Publication details

Journal / source
Pathogens
Volume
15
Issue
2
Pages
147–147
Publication date
29 January 2026
Language
EN