Trivalent Peptide Design for Bevacizumab Salt-Induced Affinity Precipitation

International Congress on Health Innovation (INOVATEC) 2026 Open access

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Authors: Joaquín A. Eloy, Gabriela R. Barredo‐Vacchelli, Jésica A. Rodríguez, Barbara Richichi, Marco Marradi, Silvia Andrea Camperi
DOI: 10.3390/proceedings2026137058
Cited by: 0

Abstract

Bevacizumab antibody binds vascular endothelial growth factor (VEGF) inhibiting blood vessels growth, avoiding tumours expansion. During its production, its purification is performed using protein-A affinity chromatography, which highly increases its overall production cost. In this work, an affinity-based precipitation has been designed with a trivalent peptide corresponding to the VEGF epitope that interacts with bevacizumab.

Fields of Study & Subjects

Protein purification and stability Monoclonal and Polyclonal Antibodies Research Chemical Synthesis and Analysis

Publication details

Journal / source
International Congress on Health Innovation (INOVATEC)
Pages
58–58
Publication date
27 February 2026
Language
EN