Yeast-Derived Postbiotics for Prevention of Enteric Diseases in Farm Animals: Current Insights and Future Perspectives

Enteric diseases are a leading cause of morbidity and economic loss in livestock production, and the search for effective, antibiotic-free alternatives has intensified in recent years. Among emerging strategies, yeast-derived postbiotics—non-viable microbial cells and their metabolites—have gained attention for their potential to enhance gut health and disease resistance in farm animals. This review synthesizes current knowledge on the composition, mechanisms of action, and practical applications of yeast postbiotics, particularly those derived from Saccharomyces cerevisiae and related species. Key bioactive components, such as β-glucans, mannan oligosaccharides, peptides, and organic acids, are discussed in the context of their immunomodulatory, anti-inflammatory, and pathogen-inhibitory properties. Evidence from in vivo and in vitro studies across multiple livestock species—including poultry, swine, and ruminants—demonstrates beneficial effects on intestinal barrier function, microbial balance, and performance under disease-challenged conditions. Despite promising outcomes, challenges remain in standardizing postbiotic preparations, elucidating dose–response relationships, and tailoring applications to species-specific needs and production systems. This review highlights the potential of yeast postbiotics as a sustainable tool in enteric disease management and outlines research priorities for their broader implementation in animal agriculture.