Microbial Quality Assessment of some Manufactured and Manually Packaged Eye and Nasal Drops Thuraya Ahmed Mohammed and Arafa Eisa Adam Hamdan

This study aimed to determine the magnitude and pattern of microbial contamination of eye and nasal drops. Method: sixty samples collected from different pharmacies in Khartoum State, Sudan. The samples were divided into three groups; group (A) “eye drops” containing chloramphenicol, group (B) manufactured “nasal drops” containing normal saline and group (C) manually packaged in pharmacies, drops containing normal saline for both eye and nose. Results: Microbial identification methods were performed, bacteria and fungi were isolated (B = 36) isolates and (C = 51) isolates respectively, their percentages were Staphylococcus aureus (25% and 19.608%), Bacillus sp (0% and 3. 922%), Escherichia coli (2.8% and 3. 922%), Proteus sp (11.11% and 9.803%), Citrobacter sp (52.8% and 5.882%), Klebsiella pneumonia (8.3% and 0%) and Pseudomonas aeruginosa (0% and 3.922%) % . The most common isolated fungi were Saccharomyces serivicae (3.33% and 5.490%), Aspergillus nigar (2.8% and 9.803%) %, Aspergillus flavus (5.55% and 5.882%) %, Penicillium sp (5.55% and 3.922%), Rhizubus sp (2.8% and 3.922%), Candida albicans (0% and 1.960%) and Actinomycetes (0% and 1.960%) Group A that contain chloramphenicol was (0%) isolate. Lipopolysaccharides been detected. Conclusion: Group A containing chloramphenicol is free from microorganism while group B and C are contaminated and do not meet the microbiological quality standards.