Factors affecting the severity of cognitive deficit in patients with schizophrenia and alcohol dependence syndrome

The aim of the study was to identify clinical, anamnestic, and socio-demographic factors associated with the severity of cognitive deficit in patients with schizophrenia comorbid with alcohol dependence syndrome. Forty-five patients aged 18-45 years in stable pharmacological remission were examined. Cognitive functioning was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS); executive functions were additionally evaluated. Anamnestic data were collected and analyzed using multivariable approaches. Higher indicators of disease severity and alcohol dependence burden were associated with more pronounced cognitive impairment. The findings highlight the need for integrated management of patients with the dual diagnosis.