Influence of a mineral-enriched preventive toothpaste on the elemental composition of saliva in patients with systemic diseases

Relevance . One of the promising approaches to the prevention of oral diseases involves the use of preventive toothpastes enriched with bioavailable essential minerals. However, the effectiveness of such formulations and their impact on salivary mineral balance in patients with concomitant systemic diseases remain insufficiently investigated. Materials and methods . The effect of a preventive toothpaste enriched with macroand trace elements on changes in salivary concentrations of calcium (Ca), copper (Cu), iron (Fe), magnesium (Mg), phosphorus (P), and zinc (Zn) was evaluated in three groups of patients (25 individuals per group): (1) chronic kidney disease, (2) cardiovascular disease, and (3) gastrointestinal disorders. Saliva samples were analyzed using electrothermal atomic absorption spectrometry with a graphite furnace (KVANT.Z.1 spectrometer, Kortek, Russia). Measurements were performed at the following time points: before tooth brushing, immediately after brushing, and 5, 30, and 60 minutes postbrushing. Results. Single use of the tested toothpaste resulted in statistically significant short-term alterations in the elemental composition of saliva, with patterns varying depending on the underlying systemic condition. The most pronounced statistically significant changes were observed for calcium and magnesium, as well as for the trace elements copper and zinc. Conclusion. The findings indicate the importance of considering the patient’s systemic health status when selecting individual oral hygiene products.