First short-term European experiences with dual-chamber leadless pacing: Early safety and electrical outcomes compared with transvenous systems

BACKGROUND: Leadless pacemakers (LPMs) eliminate the need for transvenous leads and subcutaneouspockets. However, comparative real-world data between dual-chamber LPMs and conventionaltransvenous pacemakers are lacking to date. AIMS: Our aim was to present the first single-center experience with dual-chamber LPM and tocompare early electrical performance, safety, and 90-day clinical outcomes with contemporarydual-chamber transvenous systems. METHODS: This investigator-initiated registry included consecutive patients undergoing dual-chamber pacemaker implantation: 178 dual-chamber transvenous pacemakers (2023-2024) and 27 dual-chamber LPMs (2024-2025). Leadless implantations were performed as two stages due toreimbursement regulations. Baseline characteristics, procedural parameters, electrical performanceat implantation and 90 days, and complication rates were analyzed. RESULTS: Patients receiving LPMs had a higher prevalence of prior device infection (22.2% vs. 1.1%;P