Impact of Loop Diuretics on Long-Term Kidney Outcome
Abstract
KEY POINTS: Renin-angiotensin system inhibitors have less effect on decline in eGFR and no greater effect on delaying ESKD/KRT in patients receiving loop diuretics compared with those who do. Although loop diuretic use was not associated with higher rates of ESKD/KRT, it might be associated with a higher mortality. The decline in eGFR was slower in those taking loop diuretics. BACKGROUND: In the STOP-Angiotensin-Converting Enzyme Inhibitor trial, patients with advanced CKD were randomized to continue or stop renin-angiotensin system inhibitors (RASi) and showed no difference in kidney outcomes. This post hoc analysis investigates interactions with loop diuretic use. METHODS: Patients with eGFR
Fields of Study & Subjects
Chronic Kidney Disease and Diabetes
Renin-Angiotensin System Studies
Acute Kidney Injury Research
Publication details
- Journal / source
- Kidney360
- Volume
- 7
- Issue
- 4
- Pages
- 777–785
- Publication date
- 20 January 2026
- Language
- EN