Transcriptional and Epigenetic Plasticity Drive an Alternative Non-clonal Mechanism of Resistance to Kras G12D Inhibition in Pancreatic Cancer

癌症：英文版 2026 Open access

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Authors: Alessia Caggiano, Antonio Agostini, Diego Iacuone, Lorenzo Priori, Annachiara Esposito, Anna Ceccarelli, Diego de la Rosa, Davide Pasini, Stefano Ugel, Francesco De Sanctis, Federica Cinti, Claudio Sette
+7 more Gian Luca Rampioni Vinciguerra, Clara Dezi, Vincenzo Bronte, Geny Piro, Vincenzo Corbo, Giampaolo Tortora, Carmine Carbone
DOI: 10.34133/cancomm.0030
Cited by: 1
References: 10

Abstract

Transcriptional and epigenetic plasticity drive an alternative non-clonal mechanism of resistance to KRASG12D inhibition in pancreatic cancer

Fields of Study & Subjects

Protein Kinase Regulation and GTPase Signaling Endoplasmic Reticulum Stress and Disease Hereditary Neurological Disorders

Publication details

Journal / source
癌症：英文版
Publisher
American Association for the Advancement of Science (AAAS)
Volume
46
Pages
0030–0030
Publication date
1 January 2026
Language
EN