Research into novel anxiolytics among selective carbonic anhydrase II inhibitors

Objective. To identify new anxiolytics among selective carbonic anhydrase II inhibitors. Materials and methods. The study involved nine new selective carbonic anhydrase II (CAII) inhibitors, which are sulfonamide derivatives with laboratory codes B1–3, B10–13, B18, and B24. The open field, elevated plus maze, and tail suspension tests were used. Two types of animals were examined: mice and rats. Statistical processing was performed using Microsoft Excel and Biostatistics software. Results. Both in experiments on rats and mice, compound B24 exhibits anxiolytic and antidepressant activity, while also enhancing the cognitive functions of animals. Compounds B10, B12, and B18 potentially possess anxiolytic effects, while B13 exhibits antidepressant activity. С onclusion. The study results indicate that new drugs from selective carbonic anhydrase II inhibitors possess anxiolytic and antidepressant activity while improving cognitive functions in animals.