On the issue of acute toxicity of wollastonite/HAP graft

Aim. To evaluate the biochemical and hematological blood parameters of laboratory animals in response to the implantation of wollastonite/hydroxyapatite (wollastonite/HAP) ceramics produced by template synthesis. Materials and methods. The wollastonite/HAP biocomposite used in the experiment was obtained by spark plasma sintering. Five female New Zealand White rabbits weighing between two and a half and three kilograms were selected as a model for studying acute toxicity in animals. Wollastonite/HAP was implanted under the latissimus dorsi muscles of the test animals. Biochemical and hematological parameters were assessed after blood sampling prior to implantation (control) and on the fifth day after implantation. Results. In animals, the main hematological and biochemical blood parameters were within normal limits, although a number of minor changes within the reference values of the indicator were noted. There was a decrease in total blood protein to 50.8 ± 1.64 g/L and albumin to 34.44 ± 1.30 mmol/L, possibly due to the fact of the surgical intervention. Conclusion: The data obtained on hematological and biochemical blood parameters suggest that implants produced from the wallastonite/HAP biocomposite do not exhibit acute toxicity. They therefore appear to be suitable for use in marking the edges of postoperative wounds.