Efficacy and tolerability assessment of complex therapy for drug-associated lesions of the upper gastrointestinal tract

Objective. To evaluate the efficacy and tolerability of complex therapy for NSAID- and SAID-associated lesions of the upper gastrointestinal tract using standardized and combined pharmacotherapy. Materials and methods. A total of 34 patients with erosive and ulcerative drug-associated lesions of the stomach and/or duodenum were examined. Patients in the main group ( n = 18) underwent standardized therapy (proton pump inhibitors, synthetic prostaglandin E1 analogues, antacids) in combination with a complex of pectin (soluble dietary fibre) / sea cucumber extract. The second (comparison) group ( n = 16) received only standardized therapy. Results. The patients receiving complex therapy (the main group) exhibited statistically significant improvements in the epithelialization of the gastric and/or duodenal mucosa as opposed to the comparison group. Conclusion. Adding pectin (soluble dietary fiber) and sea cucumber extract to standard NSAID and SAID gastropathy treatment increases its efficacy significantly, providing a solid basis for preventing and treating drug-induced damage to the upper gastrointestinal tract.