Design and characterization of biopolymer-based core-shell particles for sustained release of adenosine in tissue regeneration

The treatment of chronic wounds remains a formidable challenge in regenerative medicine, necessitating multifunctional biomaterials capable of modulating inflammation, promoting angiogenesis, and enabling sustained drug delivery [1]. This study presents a novel class of core–shell aerogel particles engineered from silk fibroin (SF), silk sericin (SS), and alginate (ALG), designed for the controlled release of adenosine (ADO)—a nucleoside with anti-inflammatory and pro-regenerative properties [2]. Using coaxial prilling and supercritical CO? drying, two architectures were fabricated: SF/ALG cores enveloped by ALG or ALG/SS shells.