Phenylzinnverbindungen

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) and the Pregnancy Risk Group of phenyltin compounds [e. g. 76‐87‐9 for triphenyltin hydroxide]. Phenyltin compounds are carcinogenic. Inhalation of 0.3 g triphenyltin hydroxide/m3 results in haematological and biochemical changes in rats. A concentration of 0.014 mg triphenyltin hydroxide/m3 shows no effects. A MAK value of 0.002 mg tin/m3 had been set. This value is now reaffirmed even considering the increased respiratory volume at the workplace (see List of MAK and BAT values, chapters I b and I c). Since a systemic effect is critical, Peak Limitation Category II is retained. The default excursion factor of 2 is confirmed because of the highly cytotoxic effects of phenyltin compounds. Phenyltin compounds had been classified in Pregnancy Risk Group C because the NAEC for developmental toxicity is 0.09 mg tin/m3 for rabbits. There is no new data on developmental toxicity. This classification is retained even considering the increased respiratory volume at the workplace.