Effects of Letrozole Administration on Metabolic, Inflammatory, and Oxidative Responses in Rat Serum and Brain Tissue

Letrozole is a drug that reduces estrogen synthesis and is used in the treatment of breast cancer. Its long-term use may cause systemic and neurological effects. In this study, biochemical, inflammatory, and neurological parameters were examined in female rats administered Letrozole. The study consisted of control and Letrozole groups (1 mg/kg for 21 days), each with 6 rats. On day 21, blood and brain tissue samples were collected from the rats. Proinflammatory cytokines and Aβ₁₋₄₀ levels were measured by ELISA, total antioxidant status (TAS) and total oxidant status (TOS) levels by Relassay kits, and biochemical parameters and minerals by an autoanalyzer. Analyses showed significant increases in total protein, albumin, glucose, and serum sodium levels, and a decrease in urea in the Letrozole group (P0.05). Triglyceride and total cholesterol levels in brain tissue increased significantly (P