A Clinical Case of Palliative Care during the Progression of a Patient with Advanced Lung Cancer Undergoing Gefitinib Therapy and Subsequent Transition to Osimertinib: The Role of Palliative Care in Oncology

The article presents a clinical case of a 65-year-old female patient with stage IV adenocarcinoma of the right lung harboring an EGFR-mutated (L858R). The key feature of this case is the sequential modification of targeted therapy: initial stabilization with osimertinib, transient progression with associate complications during Gefitinib therapy, and subsequent restoration of disease control following reintroduction of osimertinib. A comprehensive palliative care approach is described in detail, including repeated thoracenteses, long-term pleural drainage, and supportive therapy aimed at symptom control and maintenance of the patient’s functional status. This case highlights the importance of integrating palliative interventions into oncological practice from the early stages of treatment, as well as the advantages of original targeted agents in overcoming tumor resistance.