MICROBIOME-BASED NEUROPROTECTION: PROBIOTICS IN ALZHEIMER’S DISEASE (AD) AND PARKINSON’S DISEASE (PD)

Science and Culture 2026 Open access

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Authors: SOMA RAJAK, Sudipta Kumar Das, SOUPTIKA PATRA, ABIDITA CHAKRABARTY, SANDHIMITA MONDAL
DOI: 10.36094/sc.v92.2026.microbiome_based_neuroprotection.rajak.142
Cited by: 0

Abstract

Parkinson's disease (PD) and Alzheimer's disease (AD) are major neurodegenerative disorders whose progression is influenced by gut microbiota, stress, and diet.This study evaluates the therapeutic effects of probiotics on cognition and neuroinflammation in AD and PD, and examines how microbiota-derived short-chain fatty acids (SCFAs) modulate immune, endocrine, and neuronal pathways.Probiotics enhance barrier integrity, regulate neurotransmission, improve metabolic and inflammatory markers, and counter HPA-axis hyperactivation, while SCFAs further support neuroprotection by modulating microglia, gut hormones, and neurotransmitter synthesis.

Fields of Study & Subjects

Gut microbiota and health Probiotics and Fermented Foods Parkinson's Disease Mechanisms and Treatments

Publication details

Journal / source
Science and Culture
Volume
92
Issue
January-February
Pages
142–145
Publication date
9 February 2026
Language
EN