AN OBSERVATIONAL CROSS SECTIONAL STUDY OF THE RELATION BETWEEN GLYCOSYLATED HEMOGLOBIN A1C AND THE SEVERITY OF CORONARY ARTERY DISEASE IN NON DIABETIC PATIENTS PRESENTING TO TERTIARY CARE CENTRE IN SOUTH WESTERN MAHARASHTRA

Glycosylated hemoglobin (HbA1c) reflects average blood glucose levels over the preceding two to three months and is widely used for diabetes diagnosis and monitoring.However, its relationship with coronary artery disease (CAD) severity in non-diabetic patients remains inadequately explored.This observational cross-sectional study was conducted in a tertiary care center in South Western Maharashtra and included 140 non-diabetic patients presenting with acute coronary syndrome who underwent coronary angiography.CAD severity was categorized based on the number of significantly diseased vessels.The study demonstrated a progressive rise in mean HbA1c levels with increasing angiographic severity of CAD.Patients with prediabetic HbA1c levels showed significantly higher prevalence of multivessel disease compared to those with normal HbA1c levels.A strong positive correlation was observed between HbA1c and CAD severity, and HbA1c emerged as an independent predictor of severe coronary involvement.The findings suggest that HbA1c, even within non-diabetic range, may serve as a useful marker for cardiovascular risk stratification in acute coronary syndrome.