Outcomes Of Infant Acute Lymphoblastic Leukaemia; An Experience From Low Middle Income Country

Background: Acute Lymphoblastic Leukaemia (ALL) is the most common pediatric malignancy. This study was done to describe the prognostic factors and course of infant ALL in Pakistan. Methods: This retrospective observational study was performed at the department of Paediatric Oncology/Haematology, CMH Hospital Rawalpindi, Pakistan, from January 2012 to December 2023. Data of infants with confirmed diagnosis of ALL by immunophenotyping and treated as per Interfant 06 protocol were analyzed. Non-probability consecutive sampling technique was adopted. Disease risk stratification was done based on clinical and laboratory markers. Prognostic factors, overall survival (OS), and disease-free survival (DFS) were documented. Statistical analysis was performed using IBM-SPSS Statistics, Version 26.0. Results: In a total of 47 infants, there were 25 (53.2%) male, and the median age was 9.00 (6.00-10.00) months. Age (p