Breast cancer - when to genetically test first-degree relatives of patients with hereditary predisposition
Abstract
Familirn forma karcinomu prsu pedstavuje klinicky vznamnou podskupinu onemocnn spojenou s ptomnost germinlnch mutac v genech BRCA1, BRCA2 a dalch predispozinch genech. lnek shrnuje souasn doporuen pro genetick testovn pbuznch pacientek s prokzanou nebo suspektn hereditrn zt, vetn kritri indikace, doporuench postup genetickho poradenstv a stratifikace rizika. Dle jsou diskutovny strategie dispenzarizace a individualizovanho screeningu s clem asn detekce malignit a snen mortality v rizikov populaci. Text zdrazuje vznam mezioborov spoluprce a integrace genetickch informac do klinickho rozhodovn.
Fields of Study & Subjects
BRCA gene mutations in cancer
Breast Lesions and Carcinomas
Genetic factors in colorectal cancer
Publication details
- Journal / source
- Medicína pro praxi
- Volume
- 23
- Issue
- 1
- Pages
- 8–11
- Publication date
- 3 March 2026
- Language
- CS