Therapeutic Role of Trigonella Foenum- graecum L. Seeds Alone orCombined with Glimepiride in Mitigating Alloxan-Induced Hepatopathy inDiabetic Male Rats.

High blood sugar indicates diabetes. These problems result from insulin synthesis, action, orboth failing. Insulin insensitivity or beta cell malfunction may cause it. Ginger, garlic, and Fenugreekare used to treat diabetes. Diabetes, obesity, and other diseases are treated with it in the study, diabeticrats had considerable liver histology changes and combination therapy groups had mild changes.Giving Fenugreek, insulin, and Glimepiride improved liver health in diabetic rats, and using themtogether had a good impact on liver function. Fifty male Wistar rats were divided into five groupsand type 2 diabetes was induced by feeding a high-fat unsaturated diet followed by intraperitonealinjection of Alloxan (80 mg/kg) B.W. After one month of feeding on a high-fat diet induced diabetesmellitus (DM). The aim of this study to examine the effect of water extracted of Trigonella Foeneumgraecum L. seeds on glucose metabolism and liver function in diabetic rats. Results indicated that theoral administration of water extracted of Trigonella Foeneum graecum L. seeds not only improvedinsulin sensitivity but also contributed to the overall restoration of liver health in the affected subjects.Seeds in the reduction of blood glucose and the reduction of the pathological effect on liver and bodyweight as an experimental animal model. In conclusion, the current study shows increase in the bodyweight of rats during feeding on high fat diet for one month except group one which feeding onnormal diet. To induced type 2 diabetes and we notice the rat's weight loss and high blood sugar overthe last three weeks after injection intraperitoneal of rats by Alloxan to induced the DM. somepotential benefits of Fenugreek use. Oral Fenugreek showed improvements in blood glucose and liverfunctions (AST, ALP and ALT levels) were reduced following Fenugreek treatment. Despite asignificant decrease in Triglyceride levels, Fenugreek use did not significantly alter Cholesterollevels. Higher doses and longer Fenugreek treatment duration are recommended for the optimumprotection of the liver.