Marchiafava-Bignami Disease: A Case Study
Abstract
Marchiafava-Bignami disease is a rare neurological condition characterised by necrosis and demyelination of the corpus callosum, usually associated with chronic alcoholism and/or malnutrition. The clinical manifestations of Marchiafava-Bignami disease are diverse and often non-specific. The diagnosis of Marchiafava-Bignami disease is based on magnetic resonance imaging results, which reveal significant and symmetrical damage to the corpus callosum. We report the case of a 63-year-old man with chronic alcoholism who had been experiencing symptoms of confusion for several days. Brain CT imaging revealed diffuse and complete damage to the corpus callosum, characteristic of a severe form of Marchiafava- Bignami disease.
Fields of Study & Subjects
Alcoholism and Thiamine Deficiency
Neurological diseases and metabolism
Electrolyte and hormonal disorders
Publication details
- Journal / source
- SAS Journal of Medicine
- Volume
- 12
- Issue
- 01
- Pages
- 61–63
- Publication date
- 28 January 2026
- Language
- EN