Methylene Blue Vital Staining in Diagnosis of Oral Lesions: A Narrative Review

Global Academic Journal of Dentistry and Oral Health 2026 Open access

Read full text
Authors: Dr. T Maheswaran, Dr. M. Radhika, Siccandar Ali Jeelani, Dr. I. Janani, Dr. S. Kokila, M Saranya
DOI: 10.36348/gajdoh.2026.v08i01.002
Cited by: 0

Abstract

Methylene blue vital staining is an emerging diagnostic adjunct for detecting potentially malignant oral disorders and malignancies. This chromophoric dye exhibits a selective affinity for dysplastic and neoplastic tissues through acidophilic binding to nucleic acids. Recent evidence has demonstrated promising sensitivity and specificity profiles, positioning methylene blue as a cost-effective and minimally toxic alternative to toluidine blue for community-based screening programs. However, its role remains complementary to histopathological examination, the definitive diagnostic standard.

Fields of Study & Subjects

Oral Health Pathology and Treatment Biological Stains and Phytochemicals Head and Neck Cancer Studies

Publication details

Journal / source
Global Academic Journal of Dentistry and Oral Health
Volume
8
Issue
01
Pages
4–6
Publication date
7 January 2026
Language
EN