Effectiveness of Myrrh in dentistry, A narrative review

Background: Myrrh is a natural plant with a long history of traditional use as analgesic, for treating inflammatory, infectious, and wound-related conditions. Recently, growing scientific interest has focused on its potential applications in dentistry and oral medicine. Objective: The objective of this narrative review is to summarize and critically evaluate published strength of evidence on the use of myrrh in dentistry and oral medicine. The review focuses on pharmacological properties, formulation methods, clinical applications, safety profile, and current research gaps Methods: A comprehensive literature search was conducted using electronic databases including PubMed, Scopus, and Google Scholar, from July to November 2025. Relevant in vitro studies, animal experiments, clinical trials, and review articles investigating the dental and oral applications of myrrh were included. Data were analyzed qualitatively, focusing on antimicrobial, anti-inflammatory, analgesic, antioxidant, and wound-healing effects relevant to oral health. Results: The reviewed studies indicate that myrrh demonstrates analgesia for certain oral condition, antimicrobial activity against several oral pathogens, along with anti-inflammatory and antioxidant effects that may support oral wound healing and symptom relief. Clinically, myrrh has been formulated as gels, mouthwashes, and topical preparations, showing potential benefits in managing oral ulcers, gingivitis, and other oral mucosal conditions. However, significant variability exists in extraction methods, formulations, dosages, and study designs. Conclusion: Myrrh appears to be a promising adjunctive therapeutic agent in dentistry and oral medicine. Nevertheless, the current evidence is limited by heterogeneity and a lack of standardized protocols. Further well-designed, randomized clinical trials using standardized myrrh formulations are required to establish its efficacy, safety, and clinical applicability.