Effect of sodium thiosulfate on fi ltration and reabsorption processes in the kidneys of rats with experimental acute kidney injury

Being one of the key representatives of the group of biologically significant gases, along with nitrogen oxide and carbon monoxide, hydrogen sulfide demonstrates pronounced antioxidant properties, suppressing inflammatory processes and exerting a protective effect on tissues in various diseases. THE AIM : to study the effect of sodium thiosulfate on filtration and reabsorption processes in rats with acute renal injury (AKI). MATERIALS AND METHODS : AKI was modeled by a single intramuscular injection of 50% glycerol solution (10 ml/kg). Sodium thiosulfate was administered intraperitoneally at a dose of 0.1 g/kg every other day for three days. RESULTS : Experimental data show that the use of sodium thiosulfate significantly reduces the negative effects of intoxication caused by the administration of glycerol to animals. After administration of the drug, the damaged structures of the renal epithelium were restored, signs of inflammation and oxidative stress were eliminated, and creatinine and urea levels returned to normal. Our results demonstrate an increase in the levels of sodium and chlorine ions in the blood plasma of animals treated with sodium thiosulfate, which reflects an improvement in kidney condition and restoration of the main transport processes. CONCLUSION : Thus, sodium thiosulfate, due to its antioxidant properties, neutralizes free radicals and suppresses oxidative stress caused by glycerol, as evidenced by changes in the concentration of urea nitrogen, creatinine in plasma and daily diuresis and restoration of electrolyte balance in plasma and urine in rats treated.