Comparative analysis of the effect of lisinopril and valsartan on the results of dynamic nephroscintigraphy in chronic pyelonephritis with arterial hypertension

Bacterial infections currently pose a threat to human health, and in some cases, life. Urinary tract infections are a significant threat among them. Chronic pyelonephritis (chrPN), as a common cause of chronic kidney disease (CKD), is of significant importance in this regard. THE AIM : to study the clinical and functional effects of antihypertensive drugs in patients with symptomatic arterial hypertension (AH) in the early stages of CKD due to chrPN, using a comparative analysis using dynamic renal scintigraphy. PATIENT AND METHODS . Our study included 100 patients with CPN and hypertension, CKD C1-C3a, in remission. RESULTS . Target blood pressure was achieved with ACE inhibitors and ARBs for 2 months. Estimated glomerular filtration rate (eGFR) did not change significantly. Lisinopril therapy had no effect on Tmax and Tmax–T½ in both kidneys. Improvement in secretory and excretory function in both kidneys was observed with valsartan. CONCLUSION . A positive effect of valsartan was observed, suggesting it as a more promising drug for renal protection in patients with chronic kidney disease and hypertension.