Synergy Between GLP-1 Receptor Agonists, Nutritional Therapy, and Physical Exercise in Optimising Body Composition and Cardiometabolic Health
Abstract
Therapy with glucagon-like peptide-1 (GLP-1) receptor agonists has revolutionized the treatment of obesity and metabolic dysfunctions. However, the rapid weight loss induced by these drugs raises clinical concerns regarding depletion of fat-free mass and reductions in bone mineral density. This short communication synthesizes the recent literature on the physiology of GLP-1 receptor agonists, highlighting the non-negotiable need for multidisciplinary interventions. The integration of appropriate nutritional management with periodized resistance training emerges as the gold standard to mitigate the risk of secondary sarcopenia and to potentiate systemic adaptations to treatment.
Fields of Study & Subjects
Diabetes Treatment and Management
Pharmacology and Obesity Treatment
Nutrition and Health in Aging
Publication details
- Journal / source
- Periódicos Brasil Pesquisa Científica
- Volume
- 5
- Issue
- 1
- Pages
- 2201–2205
- Publication date
- 1 March 2026
- Language
- EN