Green Synthesis and Biological Evaluation of Mixed Ligand Metal Complexes for Enhanced Antimicrobial Potential

The increasing prevalence of multidrug-resistant microbial strains has intensified the demand for novel antimicrobial agents with improved efficacy and reduced toxicity. The metal-based therapeutics especially mixed ligand metal complexes have become promising candidates with the advantage of structural variety and increased biological activity. The current paper is dedicated to the ecofriendly synthesis of mixed ligand metal complexes through greener syntheses and their antimicrobial activity in relation to chosen pathogen microorganisms. Plant-based synthesis methods were utilized in order to minimize environmental influence without compromising on the efficiency of formation of complexes. The formation of successful complexes of metal was confirmed by Spectroscopic characterization which comprised of UV-Visible spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), and elemental analysis. Antimicrobial activity of the complexes produced was determined by the standard microbiological tests against Gram positive and Gram-negative bacterial strains and fungal pathogens. The findings showed that mixed ligand complexes had overwhelming antimicrobial publications than their parent ligands and metal salts because of heightened lipophilicity and permeability through the cell membrane. The paper builds a correlation between coordination chemistry and biological efficacy and shows relevance of the green chemistry strategies in the development of pharmaceuticals. The results have the advantage of developing greener synthesis methods and a basis on which the new class of future antimicrobials becomes implemented.