Study of antiallergic properties and toxicity of aqueous dispersion of fullerene C60 on laboratory animals

AIMS: To evaluate the antiallergic activity of an aqueous dispersion of fullerene C60 (ADF) and its safety in preclinical studies. MATERIALS AND METHODS: Food allergy was induced in BALB/c mice by ovalbumin. ADF was administered intragastrically in different regimens. Specific IgE, Th2 cytokines, body weight, diarrhea, and jejunal histology were assessed. Allergenicity was tested in mice and guinea pigs using standard hypersensitivity assays, and immunotoxicity was evaluated in humoral, cellular, and phagocytic immunity models. RESULTS: ADF reduced OVA-specific IgE, IL-4 and IL-5, alleviated diarrhea, and supported weight gain. Histology showed decreased eosinophilia in the jejunum. No allergenic or immunotoxic effects were detected in preclinical tests.