Drug allergy to folic acid — myth or reality?

Drug allergy is one of the most interesting and complex issues that a doctor of any speciality may encounter in their practice. Patients often seek medical help due to the development of certain symptoms after taking medication. Accordingly, the study of drug allergies remains a pressing concern in modern medicine, including allergology, taking into account the increase in the number of pharmacological drugs available on the market, the duration of drug use in global practice, and the development of pharmacotherapy for various nosologies. The main causative drugs of drug hypersensitivity are antibiotics and non-steroidal anti-inflammatory drugs. Folic acid (vitamin B) is a rare trigger of drug allergies. It is a water-soluble vitamin that can enter the body in food or in the form of a synthetic analogue as a drug. Folic acid preparations are found in protocols for the treatment of anaemia, as combination therapy with methotrexate, and in a number of other cases. Currently, there are only a few reported cases of drug allergy to folic acid. Skin testing confirmed an immediate-type drug allergy to folic acid. This article presents a clinical case of anaphylaxis after taking folic acid. Skin testing confirmed an immediate-type drug allergy to folic acid.