Association of Calcitonin Gene-Related Peptide Levels with Cardiovascular Disease in Hypertensive Male Patients

OBJECTIVE: Aim:The current study aimed to investigate the association between CGRP, lipid profile, and atherogenic indices in hypertensive male patients with respect to cardiovascular risk. PATIENTS AND METHODS: Materials and Methods: Fifty-four male HTN patients and 45 healthy controls (ages 51-69) were enrolled. The subjects were divided into two subgroups according to LAP: Group 1 was HTN patients with LAP (≤50), and Group 2 was HTN patients with LAP >50. Serum CGRP (pg/mL) was measured via ELISA; lipid profiles and atherogenic indices were assessed spectrophotometrically. RESULTS: Results: The mean values of WHR, VAI, LAP, SBP, DBP, atherogenic indices, and lipid profile in the HTN patients showed a statistically significant increase compared to the control, except CGRP and HDL-C, which revealed a significant decrease (P < 0.001). Also, the G2 displayed a decrease in CGRP compared to the G1. After adjusting for main hazard factors, the relation between CGRP and CVD remained significant in the multivariate analysis. The curve of ROC based on CGRP levels to indicate the existence of CVD in HTN patients was 0.80. Additionally, the AUC of CGRP was 0.82 in patients with a LAP greater than 50, compared to those with a LAP less than 50. CONCLUSION: Conclusions: These findings indicate that reduced CGRP levels are significantly associated with higher CVD risk in hypertensive men, suggesting that CGRP may be explored as a potential biomarker for cardiovascular risk assessment in future longitudinal studies.