Prognostic implication and oncogenic role of DDIT3 in breast cancer
Abstract
Although DNA damage-inducible transcript 3 (DDIT3) has been identified as a novel gene associated with breast cancer, its clinical significance, biological function, and underlying mechanisms remain unclear. By integrating immunohistochemistry with data from The Cancer Genome Atlas (TCGA), we discovered that elevated levels of DDIT3 Messenger RNA and protein expression are significantly associated with poor prognosis in patients with breast cancer. Functional assays and preliminary mechanistic studies reveal that DDIT3 may promote breast cancer cell proliferation and metastasis, potentially by downregulating activating transcription factor-2.
Fields of Study & Subjects
Breast Cancer Treatment Studies
Cancer-related Molecular Pathways
Endoplasmic Reticulum Stress and Disease
Publication details
- Journal / source
- Cancer Plus
- Volume
- 8
- Issue
- 1
- Pages
- 025100014–025100014
- Publication date
- 24 February 2026
- Language
- EN