Formulation, Development, And Evaluation of A Nonsteroidal Anti-Inflammatory Drug's For Bilayer Tablet

The prepared tablets were evaluated for pre-compression and post compression parameters.The loose bulk density (LBD) and Tapped bulk density (TBD) of the powders of different formulations were evaluated before the compression of powders in to tablets. The results of the Compressibility index of all the formulations ranges from 22.455% to 25.176%. Results clearly showed that the flow ability of all the formulations was good and also the powder had good compressibility. The thickness depends on the size of the punches (8 mm) and the weight of one tablet (150mg). The value of thickness ranges between 2.1±0.3 to 2.6±0.2mm.The results of friability test indicate that the tablet possesses good mechanical strength. The friability value ranges from 0.621±0.024 to 0.853±0.015.The values of tablets average weight ranging from 145±5 to 154±3mg. All the tablets passed weight variation test as the % weight variation was within the USP Pharmacopoeia’s limits of ±5% of the weight.