Iron, Fever and Cancer: An Intrinsic Gravitational–Thermogenetic Theory from Stars to Human Biology

Cancer-associated fever, localized tumour hyperthermia, iron accumulation, and solid mass formation are consistently observed clinical phenomena, yet they remain mechanistically fragmented across molecular, genetic, and inflammatory explanations. In this theory-forward article, we advance Intrinsic Gravitational Thermogenesis (IGT) as a unifying physical principle governing energy dissipation, mass clustering, and thermal retention across scales—from stellar evolution to embryogenesis and oncogenesis. Drawing on astrophysics, thermodynamics, bone–marrow physiology, and cancer biology, we propose that iron acts as a conserved thermophysical mediator linking gravitational compression in stars with metabolic–structural heat generation in tumours. This framework does not displace molecular oncology but embeds it within a deeper energetic and physical architecture, offering a scale-invariant theory of growth, fever, and pathological mass formation.