Diffuse large B-cell lymphoma in the maxillary sinus: case report

Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of non-Hodgkin lymphoma, accounting for 30-40% of cases. Symptoms are nonspecific and can range from nasal obstruction to visual disturbances, making diagnosis difficult and easily confused with benign inflammatory conditions and upper respiratory tract infections. In this article, we report the case of a 79-year-old female patient who sought care due to frontal headache and left hemifacial pain. After imaging studies, which revealed an infiltrative lesion in the maxillary sinus extending to the nasal cavity, orbit, and lateral wall, and biopsy, the patient was diagnosed with diffuse large B-cell lymphoma and referred for oncological treatment. The signs and clinical manifestations of diffuse large B-cell lymphoma (DLBCL) in the maxillary sinus are nonspecific. Diagnosis requires biopsy for evaluation, showing high proliferation of large B cells, with fibrosis and necrosis. Initial treatment for DLBCL involves chemotherapy using monoclonal antibodies.