TRANSCRIPTOMIC ANALYSIS OF XENOGENEIC IMMUNE REJECTION IN HYDRA

Acta Hydrobiologica Sinica 2026 Open access

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Authors: Li-Ping BU, Yue-Ying CHANG, Gui-Li LI, Hong-Chun Pan
DOI: 10.3724/1000-3207.2025.2025.0139
Cited by: 0
References: 37

Abstract

To investigate the molecular mechanisms of xenogeneic immune rejection in Hydra, we developed a novel grafting method using elongated conical toothbrush bristles as carriers to connect two polyp body segments. Successful chimeras were generated through homografts (between head-removed aposymbiotic and tail-removed symbiotic strain of Hydra sinensis) and xenografts (between head-removed Hydra vulgaris and tail-removed symbiotic strain of Hydra sinensis). Post-transplantation monitoring revealed significant immune rejection in xenograft chimeras: over 60% maintained structural integrity at 12h, ~40% at 24h,

Fields of Study & Subjects

Marine Invertebrate Physiology and Ecology Invertebrate Immune Response Mechanisms Xenotransplantation and immune response

Publication details

Journal / source
Acta Hydrobiologica Sinica
Volume
50
Issue
2
Pages
022606–70
Publication date
20 January 2026
Language
EN