E3 ubiquitin ligase COP1-mediated GSK3β degradation activates β-catenin signaling to facilitate colorectal cancer cell proliferation
Abstract
Colorectal cancer (CRC) remains one of the most prevalent and lethal malignancies worldwide, imposing a substantial burden on global healthcare systems [1].Despite advances in early detection and therapeutic strategies, the prognosis for patients with advanced or metastatic CRC remains poor, highlighting the urgent need to unravel the underlying molecular mechanisms driving CRC initiation and progression.COP1 (constitutive photomorphogenic 1, also known as RFWD2) was initially found in Arabidopsis as a regulator of photomorphogenesis [2].COP1 functions as a
Fields of Study & Subjects
Wnt/β-catenin signaling in development and cancer
Ubiquitin and proteasome pathways
Genetic factors in colorectal cancer
Publication details
- Journal / source
- Acta Biochimica et Biophysica Sinica
- Volume
- 58
- Issue
- 9
- Pages
- 2144–2148
- Publication date
- 9 February 2026
- Language
- EN