Analysis of the influence of Berberine on HSV-1 and RSV infections through the NRAV/Mir-299-3p/RAB5C Axis
Abstract
Coptis chinensis, an herb widely cultivated in China, Berberine (BE), the main active substance of Coptis chinensis, has been found to have excellent anti-inflammatory, bactericidal, and glucose-and lipid-lowering actions in recent years. In this study, we analyzed the effects of Herpes simplex virus-1 (HSV) and respiratory syncytial virus (RSV) on laryngeal cancer cells (HEp-2), with the aim of providing references and guidelines for future clinical applications of BE. The results of the study showed that after infection with HSV-1/RVS, the viral load and IF levels of cells increased, the activity decreased and the apoptosis increased (P
Fields of Study & Subjects
Berberine and alkaloids research
Herpesvirus Infections and Treatments
interferon and immune responses
Publication details
- Journal / source
- Boletin Latinoamericano y del Caribe de plantas Medicinales y Aromaticas
- Volume
- 25
- Issue
- 1
- Pages
- 45–57
- Publication date
- 30 January 2026
- Language
- EN