Anti-Diabetic Potential of Corn ( Zea mays L.) Silk: A Systematic Review and Meta-Analysis of Preclinical Studies

This systematic review and meta-analysis aimed to quantitatively evaluate the effect of corn silk on metabolic and oxidative stress parameters in preclinical diabetic models.After a comprehensive search across PubMed, Scopus, MDPI, and GARUDA databases, eight studies were included in this review and analysis.A random-effects model was employed to assess the pooled effect of corn silk intervention on the fasting blood glucose, insulin, superoxide dismutase (SOD), and malondialdehyde (MDA) levels compared to those of the pharmacological controls.The findings revealed that the administration of corn silk was not more effective than the control drugs in reducing the fasting blood glucose [standardized mean difference (SMD)=0.99,P