Potential of lysine succinylation as a therapeutic target for gallstone formation: An insightful strategy
Abstract
's study on lysine acetyltransferase 2A (KAT2A)-mediated adenosine monophosphate-activated protein kinase (AMPK) succinylation in cholelithiasis. Using mouse models and gallbladder mucosal epithelial cells, they found that KAT2A inhibits gallstones through AMPK K170 succinylation, thereby activating the AMPK/silent information regulator 1 pathway to reduce inflammation and pyroptosis. This study is the first to connect lysine succinylation with cholelithiasis, offering new insights and identifying succinylation as a potential therapeutic target. Future research should confirm these findings using patient samples, investigate other post-translational modifications, and use structural biology to clarify succinylation-induced conformational changes, thereby bridging basic research to clinical applications.
Fields of Study & Subjects
Gallbladder and Bile Duct Disorders
Bone health and treatments
Cholangiocarcinoma and Gallbladder Cancer Studies
Publication details
- Journal / source
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Volume
- 32
- Issue
- 1
- Pages
- 114865–114865
- Publication date
- 4 January 2026
- Language
- EN