Changes in Growth Parameters of Clinical Strains of Enterococcus faecalis under the Influence of Nisin

Background . Enterococcus faecalis strains have been found to possess active biofilm-forming ability. Therefore, patients with diseases caused by Enterococcus faecalis are prescribed antibiotics in high doses, making the development of drugs with antibiofilm activity urgent. The aim of the study was to evaluate the effect of nisin on the growth parameters of clinical strains of Enterococcus faecalis isolated from the oral cavity. Material and methods . Fifteen clinical strains of E. faecalis in the presence of nisin were studied; the duration of the adaptation phase, growth rate, and area under the curve were evaluated. Results . Nisin shows bactericidal activity against Enterococcus strains, however, the lantibiotic does not have a full antibacterial effect on the biofilm of the studied strains. Therefore, it is urgent to search for additional components with biofilm-destroying ability and to create combined preparations that increase the clinical efficacy of bacteriocins in dentistry.