Prevalence and Antibiotic Resistance Profiles of Uropathogens in Haldia, an Industrial City in Eastern India

Background: A significant health concern in the community with the highest morbidity is urinary tract infection (UTI). Moreover, age, comorbidity and bacterial drug-resistance worsen the situation. Changes in ecological and host factors plus misuse of drugs promote bacterial uropathogens becoming antibiotic-resistant. Objectives: Presently, we evaluate UTI prevalence and causative bacterial antibiotic-resistance-patterns in an industrial-town with educational-hub situated in eastern part of India. Age- and gender- wise comparison of bacterial susceptibility-resistance was performed. Materials and methods: A total 83 individuals (23 males and 60 females)from the city hospital and local pathological-centers provided urine samples maintaining proper norms. Routine microbiological/pathological tests and detailed drug-resistance screening were performed. Results: The major infecting organisms E. coli, K. pneumoniae and P. aeruginosa are prevalent with approximately 25:6:1 ratio in all age groups. But age wise,60% of >31 years group is infected by E. coli the rest two groups; 31-60 and >60 years are infected ~80% by E. coli. When compared to the WHO data, E.coli infection is more in the studied area (78% vs 67%). Genderwise, female is more affected by E. coli andmale is more affected by P. aeruginosa. Conclusions: Among patient-derived bacterial isolates, only 35.17% of antibiotics were effective against E. coli, and 23.66% were effective for Klebsiella sp. indicating a high level of resistance. In summary, E. Coli is resistant to the majority of medications. Nitrofurantoin and amikacin are found to be the most sensitive to the uropathogens