T786C AND GLU298ASP Polymorphisms Of The Nos3 Gene And Their Association With Vascular Dysfunction In Patients With Coronary Heart Disease And Type 2 Diabetes Mellitus

The impact of the T786C and Glu298Asp polymorphisms of the NOS3 gene on vascular reactivity parameters was assessed in patients with coronary artery disease and type 2 diabetes mellitus. Ninety-two patients were examined and genotyping was performed using PCR. Average linear blood flow velocity, arterial diameters before and after the functional test, and resistance and reactivity coefficients were studied. A significant decrease in vascular reactivity was found in carriers of the T/C and Glu/Asp genotypes compared to homozygotes. The identified patterns highlight the importance of NOS3 polymorphisms in the pathogenesis of vascular disorders in the combination of coronary heart disease and type 2 diabetes.