Features Of Apoptosis Regulation In Hepatic Pathology And The Role Of Inducers Of The Monooxygenase And Nitrergic Systems Of Hepatocytes

In a study on male white outbred rats with a body weight of 180-250 g, it was found that animals with OTG showed higher levels of P53 and TNFα, as well as higher levels of cytochrome C release from mitochondria. The administration of benzonal, an inducer of drug metabolism, at a dose of 50 mg/kg to animals with OTG (CCl4) significantly reduced the symptoms of apoptosis. On the other hand, the administration of cimetidine at a dose of 10 mg/kg stimulated the apoptosis of hepatocytes, which dramatically increased the levels of P53, TNFα, and cytochrome C in biological fluids. In animals with OTG, arginine, an NO L-inducer, reduced the pro-apoptotic indicators. Compared to the OTG group, the non-selective NOS inhibitor L-NAME increased the levels of P53 protein, TNFα, and cytochrome C release from hepatocyte mitochondria.