[Clinical and genetic characteristics of 15 pediatric cases of long QT syndrome type 2 caused by KCNH2 variants].

PubMed 2026

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Authors: Z Y Lyu, Y Y Xiao, Y Gu, Z Y Wang, Xiaohan Yu, L Gao, Y F Yang
DOI: 10.3760/cma.j.cn112140-20251030-00962
Cited by: 0

Abstract

The clinical phenotype of children with KCNH2 variants is closely associated with the affected functional domain. Patients with pore-domain variants exhibit more pronounced QTc prolongation and a higher risk of malignant arrhythmias. Genotype-phenotype analysis provides important insights for clinical risk stratification, treatment selection and prognosis assessment.

Fields of Study & Subjects

Cardiac electrophysiology and arrhythmias Ion channel regulation and function Cardiovascular Effects of Exercise

Publication details

Journal / source
PubMed
Volume
64
Issue
4
Pages
436–441
Publication date
14 March 2026
Language
ZH