[Idiopathic pulmonary fibrosis and lung epithelial tissue stem cell dysfunction].
Abstract
respiratory airway secretory cell (RAS), exhibit significant impairment in stemness function. This manifests as increased senescence and aberrant differentiation, resulting in a imperfect wound healing response characterized by insufficient regenerative repair of the respiratory epithelium and active fibrotic repair. Intrapulmonary transplantation of tissue stem cells for IPF patients can achieve functional reconstitution of stem cells within the remodeled epithelium, leading to improvement in fibrotic lesions and lung function. Therapeutic strategies aimed at restoring the balance of lung tissue regeneration via stem cells hold promise for achieving disease control or even reversal in IPF.
Fields of Study & Subjects
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Neonatal Respiratory Health Research
Mesenchymal stem cell research
Publication details
- Journal / source
- PubMed
- Volume
- 49
- Issue
- 1
- Pages
- 84–88
- Publication date
- 12 January 2026
- Language
- ZH