[Characteristics of uterine leiomyosarcoma: a clinicopathological and molecular genetic analysis of twenty-four cases].
Abstract
Uterine leiomyosarcoma is characterized by multiple copy number variations and gene mutations, most frequently involving TP53 and RB1. Additional common molecular features include copy number variations of homologous recombination repair-related genes, ATRX protein expression loss, low tumor mutational burden, and microsatellite stability. Secondary morphological changes in uterine leiomyosarcomas associated with hormone therapy pose significant diagnostic challenges. Next generation sequencing can provide valuable evidence for the diagnosis of morphologically challenging cases of leiomyosarcoma in clinical practice.
Publication details
- Journal / source
- PubMed
- Volume
- 55
- Issue
- 1
- Pages
- 34–39
- Publication date
- 8 January 2026
- Language
- ZH