[Clinicopathological and molecular genetic features of large B-cell lymphoma with IRF4 gene rearrangements involving the head and neck region in adults].
Abstract
LBL-IRF4 involving the head and neck in adults is not uncommon. Adult cases mimic their pediatric counterparts, showing similar morphological and immunohistochemical features. Some cases are CD5 positive and harbor bcl-6-rearrangement. Overall, it carries a favorable prognosis. Routine testing of IRF4 rearrangement is recommended for cases with the following characteristics: in the head and neck region, morphologically high-grade follicular lymphoma or diffuse large B-cell lymphoma with strong MUM-1 expression irrespective of patient age.
Publication details
- Journal / source
- PubMed
- Volume
- 55
- Issue
- 1
- Pages
- 16–21
- Publication date
- 8 January 2026
- Language
- ZH